Castro’s home run came in Houston’s four-run first inning. The White Sox scored two in the second and one in the third to cut the lead to one before Fowler’s solo shot in the fifth inning. His RBI single in the seventh inning pushed the lead to 6-3.
Houston starter Jarred Cosart (3-3) allowed seven hits and three runs in five innings.
Kyle Farnsworth had a tough debut with the Astros after being signed Saturday. Alejandro De Aza and Gordon Beckham each had an RBI off of the veteran reliever in the eighth inning to cut the lead to 6-5.