Abreu’s hitting streak ended at 21 games, longest in the AL this season. He went 0 for 3 with two walks, one of them intentional.
The Cuban rookie, who leads the majors with 31 home runs, had reached base in 10 straight plate appearances before he popped up in the first inning.
Plouffe doubled twice and drove in two runs. Oswaldo Arcia was credited with a two-run double in the eighth, giving the Twins a 7-6 lead, when his liner glanced off the glove of left fielder Alejandro De Aza.
Adam Eaton hit three doubles and a single for Chicago.
Ryan Pressly (1-0 ) won and Glen Perkins pitched the ninth for his 27th save in 30 chances.
Ronald Belisario (4-8) took the loss.