Hutchison (4-1) allowed four singles, walked none and struck out eight while throwing just 96 pitches in his second career shutout. The other came at Texas on May 16, 2014.
Smoak hit a two-run homer in the first and Donaldson had a solo drive in the second as the Blue Jays won consecutive games for the first time since a three-game streak from May 6-9.
The loss in the opener of a season-long, 11-game trip stopped a five-game road win streak for the White Sox. Chicago has lost six of seven overall.