The three-time defending national champion Huskies (5-0) have not lost since Nov. 17, 2014, an 88-86 loss to Stanford.
Stewart was dominant with her double-double, but had plenty of help. Katie Lou Samuelson and Kia Nurse each scored 10 points for the Huskies.
DePaul (5-2) was led by Jessica January, who scored 18 points. Brooke Schulte scored 12 and Chanise Jenkins finished with 10.